Placental transfer of cefotiam dihydrochloride

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Placental transfer of cefotiam dihydrochloride.

The concentrations of cefotiam dihydrochloride (CTM) in maternal and fetal blood and in amniotic fluid were determined by bioassay in 38 women at parturition. With an intravenous infusion of 1 g of CTM, the decline in concentration of CTM in maternal blood was biphasic; CTM was not detectable at 6 h after administration. Peak levels of CTM in umbilical cord blood (13.0 to 23.9 micrograms/ml) w...

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Placental transfer of choles

A tracer dose of cholester01-4-~~C was given daily in the diet of six pregnant guinea pigs to establish an isotopic steady state. At the time of parturition, maternal and fetal blood and fetal tissues were collected and analyzed for cholesterol content and cholesterol specific activity. A comparison of these specific activities in neonatal and maternal serum indicated that about 22% of the feta...

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Placental transfer of naloxone.

Maternal and umbilical venous serum naloxone concentrations were measured after the i.v. (30 mothers) or i.m. (seven mothers) injection of naloxone 400 micrograms. Following i.v. naloxone there was rapid transfer to the fetus and therapeutic plasma concentrations could be expected in 1 or 2 min. However, following i.m. administration, neonatal concentrations were variable. In five non-pregnant ...

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Placental transfer of parathyroid hormone.

We investigated the in vitro transfer of three parathyroid hormone (PTH) fragments (amino acids 35-84, 44-68 and 65-84) through human placenta at term. The perfused and transferred fragments were measured radioimmunologically and identified by three different methods: high-pressure-liquid chromatography (HPLC), preparative flat-bed electrofocusing (PEGG), and gel filtration (GF). The study demo...

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Placental transfer of fatty acids.

Information derived from animal investigations using labelled thtty acid infusions and measurements of the fatty acid concentrations found in the various fractions i n maternal and foetal umbilical artery and venous blood and tissues have shown that the net flux of fatty acid from mother t o foetus across the placenta varies greatly from species to species. In general, in those species with mat...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1984

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.25.1.147